Ghrelin in neuroendocrine organs and tumours

摘要: Ghrelin is a 28 amino-acid hormone with multiple functions. It predominantly produced by the stomach but has also been detected in other organs, including small intestine, pancreas, hypothalamus and pituitary, as well immune system almost every normal human tissue examined. present neuroendocrine tumours, pituitary adenomas, endocrine tumours of breast thyroid medullary carcinomas. brain-gut peptide growth hormone-releasing appetite-inducing activities, endogenous ligand G protein-coupled secretagogue receptor (GHS-R). In this review we comprehensively summarize available data regarding (a) expression ghrelin GHS-R tissues adenomas (b) levels circulating patients (c) effects administration these on hormones rate proliferation tumour. clear that many more functions involved processes than was initially postulated, its endocrine, paracrine autocrine play role physiological pathophysiological