Why does Inflammation persist: A Dominant Role for the Stromal Microenvironment?

摘要: Inflammatory responses occur within tissue microenvironments, with functional contributions from both haematopoietic (lymphocytic) cells and stromal (including macrophages fibroblasts). These environments are complex--a compound of many different cell types at stages activation differentiation. Traditional models inflammatory disease highlight the role antigen-specific lymphocyte attempt to identify causative agents. However, recent studies have indicated importance microenvironments innate immune response in perpetuating process. The prominent generation maintenance these has begun challenge primacy regulating chronic processes. Sensible enquiries into factors persistence necessitate an understanding mechanisms homeostasis remodelling during inflammation. This article highlights insights dynamic aspects inflammation, focusing particularly on mononuclear infiltrates, their interactions tissues relevance existing possible future therapies. A key feature current research been a growing appreciation that disordered spatial temporal between infiltrating resident lie heart persistence.