Methods of modulating serine/threonine protein kinase function with azabenzimidazole-based compounds

作者: Bernhard Kutscher , Gerald McMahon , Harald App , Heinz Weinberger

DOI:

关键词: BiochemistryKinaseSerine/threonine-specific protein kinaseReceptor protein serine/threonine kinaseSerineProtein kinase CSerine threonine protein kinaseBiologyThreonineProtein kinase A

摘要: The present invention is directed in part towards methods of modulating the function serine/threonine protein kinases with azabenzimidazole-based compounds. incorporate cells that express a kinase, such as RAF. In addition, describes preventing and treating kinase-related abnormal conditions organisms compound identified by invention. Furthermore, pertains to azabenzimidazole compounds pharmaceutical compositions comprising these

参考文章(21)
Istvan Szelenyi, Walter von Bebenburg, Klaus Thiemer, 7-Azabenzimidazoles with basic side chains and use thereof ,(1979)
D.J. Robbins, E. Zhen, H. Owaki, C.A. Vanderbilt, D. Ebert, T.D. Geppert, M.H. Cobb, Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro Journal of Biological Chemistry. ,vol. 268, pp. 5097- 5106 ,(1993) , 10.1016/S0021-9258(18)53507-9
Angelo Crugnola, Franco Buzetti, Dario Ballinari, Felicita Greco, Vinylene-azaindole derivatives and process for their preparation ,(1993)
Michael A. Eissenstat, Mark P. Wentland, John D. Weaver, Gee-Hong Kuo, 1-cyclopropyl-4-pyridyl-quinolinones ,(1992)
Ellen Myra Dobrusin, Howard Daniel Hollis Showalter, William Alexander Denny, Moana Tercel, Gordon William Rewcastle, Brian Desmond Palmer, Andrew Mark Thompson, 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties ,(1993)
Robert Lee Dow, Steven Wayne Goldstein, Benzylphosphonic acid tyrosine kinase inhibitors ,(1991)
Li Sun, Gerald Mcmahon, Peng Cho Tang, Indolinone compounds for the treatment of disease ,(1996)
D. K. Morrison, D. R. Kaplan, U. Rapp, T. M. Roberts, Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 8855- 8859 ,(1988) , 10.1073/PNAS.85.23.8855
Brett P. Monia, Joseph F. Johnston, Thomas Geiger, Marcel Muller, Doriano Fabbro, Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C- raf kinase Nature Medicine. ,vol. 2, pp. 668- 675 ,(1996) , 10.1038/NM0696-668