Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C- raf kinase

摘要: Substantial evidence exists supporting a direct role for raf kinases in the development and maintenance of certain human malignancies. Here we test potential phosphorothioate antisense oligodeoxynucleotides targeted against C–raf–1 kinase to specifically inhibit gene expression tumor progression cell culture vivo, using xenograft mouse models. Treatment cells with appropriate led specific inhibition C–raf vivo at well–tolerated doses. Moreover, oligodeoxynucleotide treatment resulted potent antiproliferative effects antitumor variety types that were highly consistent an mechanism action these compounds. These studies strongly suggest inhibitors may be considerable value as antineoplastic agents display activity wide spectrum