Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating.

摘要: The purpose of this investigation was to determine the ability tetracycline-containing fibers inhibit biofilm formation peri-implantitis-associated pathogens [i.e., Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), Prevotella intermedia (Pi), and Aggregatibacter actinomycetemcomitans (Aa)]. Tetracycline hydrochloride (TCH) added a poly(DL-lactide) [PLA], poly(e-caprolactone) [PCL], gelatin [GEL] polymer blend solution at distinct concentrations obtain following fibers: PLA:PCL/GEL (TCH-free, control), PLA:PCL/GEL + 5 % TCH, PLA:PCL/GEL + 10 % PLA:PCL/GEL + 25 % TCH. inhibitory effect TCH-containing on assessed by colony-forming units (CFU/mL). Qualitative analysis inhibition done via scanning electron microscopy (SEM). Statistical significance reported p < 0.05. Complete observed in groups containing TCH 10 25 wt%. Fibers 5 wt% demonstrated complete Aa biofilm. Even though marked reduction CFU/mL with an increase concentration, Pi proved be most resilient microorganism. SEM images revealed absence or notable decrease bacterial nanofibers. Collectively, our data suggest that hold great potential as antibacterial dental implant coating.