Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.
作者： Howard J. Edenberg , Jeanette N. McClintick
DOI: 10.1111/ACER.13904
关键词: Acetaldehyde 、 Biology 、 Genetics 、 Linkage disequilibrium 、 Alcohol 、 ALDH2 、 Ethanol metabolism 、 ADH1B 、 Aldehyde dehydrogenase 、 Alcohol dependence
摘要: Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes contribute to the risk, as does environment. Although total genetic contribution risk is substantial, most individual make only very small contributions. By far strongest contributors functional 2 involved alcohol (ethanol [EtOH]) metabolism. A variant dehydrogenase 1B (ADH1B) protective people of European and Asian descent, a different same gene those African descent. strongly aldehyde (ALDH2) essentially found Asians. This highlights need study wide range populations. The likely mechanism protection against heavy drinking AUDs both cases alteration rate metabolism EtOH at least transiently elevates acetaldehyde. Other ADH ALDH variants, including ADH1C, have also been implicated affecting behavior for alcoholism. pattern linkage disequilibrium region differences among populations complicate analyses, particularly regulatory variants. critical review focuses upon they affect AUDs.
sci-hub.se 参考文章(146)
Surendra Singh, Ying Chen, Akiko Matsumoto, David J. Orlicky, Hongbin Dong, David C. Thompson, Vasilis Vasiliou, ALDH1B1 links alcohol consumption and diabetes. Biochemical and Biophysical Research Communications. ,vol. 463, pp. 768- 773 ,(2015) , 10.1016/J.BBRC.2015.06.011
Marcella Rietschel, Jens Treutlein, The genetics of alcohol dependence. Annals of the New York Academy of Sciences. ,vol. 1282, pp. 39- 70 ,(2013) , 10.1111/J.1749-6632.2012.06794.X
Denise M. Scott, Robert E. Taylor, Health-related effects of genetic variations of alcohol-metabolizing enzymes in African Americans. Alcohol Research & Health. ,vol. 30, pp. 18- 21 ,(2007)
Howard J. Edenberg, Genes Contributing to the Development of Alcoholism: An Overview Alcohol Research & Health. ,vol. 34, pp. 336- 338 ,(2012)
Howard J. Edenberg, Holly Read Thomasson, David W. Crabb, Ru Band Lu, Shiou Ping Wang, Yu Tsai Lin, Ting Kai Li, Xiao Ling Mai, Shin Jiun Yin, Ronald E. Jerome, Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. American Journal of Human Genetics. ,vol. 48, pp. 677- 681 ,(1991)
Amy B. Hart, Kevin G. Lynch, Lindsay Farrer, Joel Gelernter, Henry R. Kranzler, Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence Addiction Biology. ,vol. 21, pp. 924- 938 ,(2016) , 10.1111/ADB.12244
Thomas D. Hurley, Howard J. Edenberg, Ting-Kai Li, Pharmacogenomics of Alcoholism Pharmacogenomics. pp. 417- 441 ,(2003) , 10.1002/3527600752.CH21
Josef Frank, Sven Cichon, Jens Treutlein, Monika Ridinger, Manuel Mattheisen, Per Hoffmann, Stefan Herms, Norbert Wodarz, Michael Soyka, Peter Zill, Wolfgang Maier, Rainald Mössner, Wolfgang Gaebel, Norbert Dahmen, Norbert Scherbaum, Christine Schmäl, Michael Steffens, Susanne Lucae, Marcus Ising, Bertram Müller-Myhsok, Markus M. Nöthen, Karl Mann, Falk Kiefer, Marcella Rietschel, Genome‐wide significant association between alcohol dependence and a variant in the ADH gene cluster Addiction Biology. ,vol. 17, pp. 171- 180 ,(2012) , 10.1111/J.1369-1600.2011.00395.X
Howard J. Edenberg, Thomas D. Hurley, Genes Encoding Enzymes Involved in Ethanol Metabolism Alcohol Research & Health. ,vol. 34, pp. 339- 344 ,(2012)
Jacquelyn L. Meyers, Dvora Shmulewitz, Melanie M. Wall, Katherine M. Keyes, Efrat Aharonovich, Baruch Spivak, Abraham Weizman, Amos Frisch, Howard J. Edenberg, Joel Gelernter, Bridget F. Grant, Deborah Hasin, Childhood adversity moderates the effect ofADH1Bon risk for alcohol-related phenotypes in Jewish Israeli drinkers Addiction Biology. ,vol. 20, pp. 205- 214 ,(2015) , 10.1111/ADB.12102