Regulation of Bcl-xL: a little bit of this and a little bit of STAT

作者: Jennifer M. Grad , Xiao-Rong Zeng , Lawrence H. Boise

DOI: 10.1097/00001622-200011000-00006

关键词: Bcl-xLHomology (biology)Proto-Oncogene Proteins c-etsMedicineCell biologyApoptosisBcl x proteinRegulation of gene expressionSTAT3 Transcription FactorstatCancer researchOncology

摘要: The Bcl-2 family of proteins are key regulators apoptosis. Bcl-xL is an anti-apoptotic protein with a high degree homology to Bcl-2; however, the signals that regulate and appear be different. Levels Bcl-xL, but not Bcl-2, increased in response various survival signal

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