Value of serum tumor markers for predicting EGFR mutations in non-small cell lung cancer patients
作者： Linfang Wen , Shenghao Wang , Weiran Xu , Xiaofeng Xu , Mei Li
DOI: 10.1016/J.ANNDIAGPATH.2020.151633
关键词: Mutation 、 Pathology 、 Oncology 、 Lung cancer 、 Egfr mutation 、 Epidermal growth factor receptor 、 Internal medicine 、 Adenocarcinoma 、 Lung 、 Mutant 、 Non small cell 、 Medicine
摘要: Abstract Objectives We investigated whether serum tumor markers (STMs) represent a valuable noninvasive tool to predict epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) patients. Methods A retrospective analysis was performed for 143 NSCLC patients at the Peking University International Hospital from December 2014 2019. EGFR tissues were identified by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and next generation sequencing (NGS). The relationships between several clinicopathological features analyzed. Result found more frequently female (56.67%, P = 0.01), never-smokers (55.26%, P = 0.004), those with adenocarcinoma (ADC) (52.17%, P Conclusion STMs are associated mutant status could be integrated other clinical factors facilitate classification of among
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