Pro-gastrin-releasing peptide as a factor predicting the incidence of brain metastasis in patients with small cell lung carcinoma with limited disease receiving prophylactic cranial irradiation
作者： Kan Yonemori , Minako Sumi , Naoko Fujimoto , Yoshinori Ito , Atsushi Imai
DOI: 10.1002/CNCR.21238
关键词: Metastasis 、 Prophylactic cranial irradiation 、 Brain metastasis 、 Lung cancer 、 Oncology 、 Cancer 、 Surgery 、 Internal medicine 、 Respiratory disease 、 Medicine 、 Conventional PCI 、 Progressive disease 、 Cancer research
摘要: BACKGROUND Prophylactic cranial irradiation (PCI) reduces the incidence of brain metastasis with an effect on overall survival in patients small cell lung carcinoma (SCLC). In spite multidisciplinary intensive treatment approaches, many still experience metastasis. The authors retrospectively analyzed characteristics first failure event due to (FBM) treated PCI. METHODS Between January 1990 and April 2004, 71 limited disease SCLC were PCI after completing systemic at National Cancer Center Hospital (Tokyo, Japan). Univariate multivariate analyses used identify factors related FBM survival. RESULTS The (OBM) 16.9 % (12 71) 26.8% (19 71), respectively. Median time progressive median 8.4 months 21.6 months, Elevation pro-gastrin–releasing peptide (Pro GRP) level before was found be a significant predictive prognostic factor for FBM, OBM, analysis (P = 0.007, P 0.025, 0.009, respectively). CONCLUSIONS An elevated Pro GRP significantly survival, should considered is performed. 2005. © 2005 American Society.
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