A concept of Helicobacter pylori and stress-secreted mast cells' potential involvement in brain metastases

摘要: We read with interest the paper by Theoharides et al. (2008), who concluded that mast cells can be stimulated corticotropin-releasing hormone, secreted under stress, to release mediators including histamine, interleukin (IL)-8, tryptase and vascular endothelial growth factor (VEGF), which disrupt blood–brain barrier (BBB) permitting metastases of lung mammary adenocarcinomas. Helicobacter pylori infection (Hp-I) appears a common denominator lung, gastrointestinal (GI) tract cancers contributing mentioned stress–mast cell–BBB disruption–brain sequence these malignancies. Indeed, apart from GI malignancies (mainly gastric cancer), Hp-I has been involved in breast (Prelipcean al., 2007; Moss Malfertheiner, Kountouras 2004), mainly via induction oncogenic gastrin contributes carcinogenesis metastasis (Yonemori 2005; Gugger Reubi, 1999); an elevated pro-gastrin-releasing peptide level before prophylactic cranial irradiation significantly related first failure event due brainmetastases survival carcinoma 2005). Physical psychological stresses are accepted as triggers and/or modifiers various disorders clinical course. Stress also synergize other pathogenic factors such Hp produce upper The brain–gut axis provides anatomical basis through emotions environmental influences modulate function regulation immune system mucosal inflammation; this regard, – at cellular corticotropin releasing (CRF), molecular level, appear play critical role (Caso 2008).