3D Shape Perception in Posterior Cortical Atrophy: A Visual Neuroscience Perspective

摘要: Posterior cortical atrophy (PCA) is a rare focal neurodegenerative syndrome characterized by progressive visuoperceptual and visuospa-tial deficits, most often due to atypical Alzheimer's disease (AD). We applied insights from basic visual neuroscience analyze 3D shape perception in humans affected PCA. Thirteen PCA patients 30 matched healthy controls participated, together with two patient control groups diffuse Lewy body dementia (DLBD) an amnestic-dominant phenotype of AD, respectively. The hierarchical study design consisted processing for 4 cues (shading, motion, texture, binocular disparity) corresponding 2D elementary feature extraction conditions. DLBD exhibited severe shape-processing deficits AD lesser degree. In PCA, deficient shape-from-shading was associated volume loss the right posterior inferior temporal cortex. This region coincided functional activation during controls. who performed same fMRI paradigm, response amplitude reduced this region. Gray matter also correlated AD. shape-from-disparity slightly more anteriorly cortex as well ventral premotor findings are consistent neurophysiologically based models anatomy processing. However, DLBD, rely on mechanisms distinct structural integrity. Significance Statement dysfunc-tion presentation (AD) affecting dorsal streams rather than medial system. fundamental were beyond what could be accounted lower-order deficits. For shading disparity, related regions previously implicated intact human nonhuman primate brain. Typical Advanced provides insight into pathogenesis that bears relevance vision typical