The −1154 G/A VEGF gene polymorphism is associated with the incidence of basal cell carcinoma in patients from northern Poland

摘要: Vascular endothelial growth factor (VEGF) is believed to play a crucial role in neoplastic angiogenesis. Although the genetic background of basal cell carcinoma (BCC) has been analyzed some papers, mechanism BCC pathogenesis not fully understood. To best our knowledge, VEGF gene polymorphisms have yet explored. The aim study was asses frequency three (−1154 G/A, −460 T/C and +405 G/C) patients Polish origin with control group. In addition, serum levels controls were measured. involved 180 (96 women, 84 men) mean age 68.9 ± 11.8, 215 healthy age- sex-matched volunteers. at positions −1154 using amplification refractory mutation system polymerase chain reaction method. assess polymorphism position −460, we used restriction fragment length Serum protein measured ELISA test. presence G allele (GA or GG) associated an increased risk development (OR = 7.28, p < 0.0001). Furthermore, carriers AA genotype showed significantly reduced risks (OR = 0.14, It also shown that GTC haplotype predisposes (OR = 1.69, p = 0.013), while ATG reduces this (OR = 0.17, p = 0.00001). We found among patients, comparison (mean 596.7 ± 393.5 pg/ml; range 60.1–931.4 vs. 255.9 ± 174.6 pg/ml; 42.2–553.0 pg/ml; p < 0.0004). correlated tumor size: r = 0.41, p < 0.0001. Our results testify importance G/A altering population from northern Poland.