Integration of the DNA Damage Response with Innate Immune Pathways

摘要: Genotoxic or replicative stress triggers a DNA damage response (DDR) that induces cell cycle arrest, repair – if the is too severe apoptosis. The DDR has been suggested to represent barrier against tumorigenesis by preventing uncontrolled proliferation of cells with genomic instability harmful mutations. Recent studies have uncovered novel links innate immune signaling pathways. activation NF-κB in mediated ATM (ataxia telangiectasia mutated)dependent phosphorylation NEMO, resulting induction classical Furthermore between and various members type I interferon (IFN) pathway uncovered. also increases sensitivity cell-mediated killing inducing expression surface ligands for activating receptors. Here, we review how pathways potential role these interactions cancer viral infection.