Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17 producing neutrophils
作者： Patricia R. Taylor , Sixto M. Leal , Yan Sun , Eric Pearlman
关键词: T cell 、 Immunology 、 Microbiology 、 Corneal Infection 、 Interleukin 17 、 Aspergillus 、 Biology 、 Aspergillus fumigatus 、 Interferon gamma 、 Fungal keratitis 、 Spleen
摘要: Fusarium and Aspergillus species of mold are major causes corneal infections in the United States worldwide, resulting severe visual impairment blindness. As there is evidence for T cell responses to these pathogenic fungi infected individuals, we examined role IL-17A (IL-17) IFN-γ murine models fungal keratitis. We found that C57BL/6 mice given intratracheal or s.c. immunization conidia prior infection exhibited enhanced killing lower opacity compared with unimmunized mice. Protective immunity was associated temporal recruitment IL-17–producing neutrophils Th17 Th1 cells dependent on production IL-17 but not IFN-γ. Protection also impaired neutrophil-depleted Rag 2 −/− Together, results studies identify an essential regulating growth hyphae severity disease.
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