Structure-activity relationships in the actinomycins.

摘要: Publisher Summary This chapter presents nomenclature of actinomycins (AMs) based on the peptide structure, which uses International Union Pure and Applied Chemistry–International Biochemistry (IUPAC–IUB) rules for naming analogs. AMs are well-known as specific inhibitors DNA-primed RNA synthesis used a biochemical tool in numerous investigations cellular events, especially macromolecular biosynthesis virus replication. The clinical use actinomycin is treatment Wilms' tumor, gestational choriocarcinoma, mixed metastatic embryonal carcinoma testis. has compiled microbiological procedures preparation chemical methods modification AM total synthesis. Analogs derivatives known structure have been listed. also describes structure-activity relationships that can at present be deduced from approximately 30 analogs isolated natural sources or produced by directed crystal solution conformations nuclear magnetic resonance (NMR) circular dichorism (CD) studies discussed.