Markers of progression and invasion in short term follow up of untreated breast cancer patients.

摘要: BACKGROUND: Cancer progression and metastasis are complex processes, dependent of molecules involved in inflammation, degradation invasion. These can be used as prognostic indicators to single out patients with higher risk recurrence. Interleukin-8 (IL-8) has a role urokinase plasminogen activator (uPA), inhibitor type-1 (PAI-1) matrix metalloproteinase-2, -9 have decisive part the process invasion, while vascular endothelial growth factor (VEGF) is consequential for angiogenesis. OBJECTIVES: Aim our study determine relations between IL-8, uPA, PAI-1, MMP-2, -9, VEGF their significance terms recurrence free survival. METHODS: This included 91 untreated lymph node negative (N0) primary breast cancer. RESULTS: Patients levels uPA (p = 0.05), PAI-1 (0.05), MMP2 0.05) IL-8 0.02) poor prognosis. Positive correlations were found ER – PR, MMP9, MMP9 VEGF. Negative CONCLUSIONS: Higher concentrations MMP2, VEGF, confirmed aggressive phenotype prognosis different subgroups.