Antioxidant and hepatoprotective properties of Indian Sunderban mangrove Bruguiera gymnorrhiza L. leave.

摘要: Background: Bruguiera gymnorrhiza L. (family Rhizophoraceae ) is a true mangrove habitat in Indian Sunderban and traditionally uses for liver disorders. Objectives: The aim was to evaluate antioxidant hepatoprotective actions of leave extract B. Materials Methods: Hydro - methanolic leaves (BR) standardized using spectrophotometric high-performance thin layer chromatography methods. Radical scavenging activities were assessed different vitro methods, like 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid + , superoxides, nitric oxides hydroxyl radicals. Hepatoprotective efficacy BR (125 mg/kg 250 mg/kg, p.o) measured D-galactosamine (GalN) induced (200 i.p) hepatitis Wistar rats. Silymarin (25 used as known agent. Results: Polyphenols such gallic acid, quercetin, coumarin obtained from exhibited powerful properties. Moreover, it produced dose-dependent protection against GalN It significantly reduced elevation enzymes (alanine transaminase, aspartate aminotransferase, alkaline phosphatase) serum resist oxidative stress marked by lipid peroxides, glutathione, catalase hepatic parenchyma. Conclusions: rich ameliorate tissue injury through its effects.