Circadian rhythms in the absence of the clock gene Bmal1.

摘要: Circadian (~24 hour) clocks have a fundamental role in regulating daily physiology. The transcription factor BMAL1 is principal driver of molecular clock mammals. Bmal1 deletion abolishes 24-hour activity patterning, one measure output. We determined whether function necessary for oscillations skin fibroblasts and liver slices. Unexpectedly, knockout mice, both tissues exhibited the transcriptome, proteome, phosphoproteome over 2 to 3 days absence any exogenous drivers such as light or temperature cycles. This demonstrates competent pacemaker knockouts. suggest that might be underpinned by transcriptional regulation recruitment ETS family factors, nontranscriptionally co-opting redox oscillations.