Discriminative aspects of two generic and two asthma-specific instruments: relation with symptoms, bronchodilator use and lung function in patients with mild asthma.

摘要: The objective of this study was to compare the two most frequently used asthma-specific quality life (QOL) questionnaires and generic QOL with clinical data in order establish their ability discriminate asthma severity, also referred as cross-sectional construct validity. We conducted a multicentre, randomized, placebo-controlled investigating long-term effects long-acting s2-agonist formoterol patients using inhaled corticosteroids short-acting s2-agonists. Before randomization, peak expiratory flow (PEF) use s2-agonists for relief symptoms were recorded twice daily 1 month. At end run-in period, forced volume 1s (FEV1), airway hyper-responsiveness (PC20 methacholine) measured, questionnaires, Asthma Quality Life Questionnaire (AQLQ) Living (LWAQ), well Short Form 36 (SF-36) Psychological General Well Being (PGWB) index. (n=110) only mildly impaired. mean symptom score 3.6 on scale 0-21 FEV1 65% that predicted. correlations between parameters measures such FEV1, PEF PC20, low (0.01-0.37). subjective scores (range 0.26-0.65) (0.09-0.39), higher. activity domains AQLQ diary-obtained r=0.50 (p[lessthan]0.0001) r=0.65 (p[lessthan]0.0001), respectively. correlation physical LWAQ r=0.42 (p[lessthan]0.001) sumscore SF-36 (p[lessthan]0.001). PGWB r=0.41 relation PC20 very low. measurements related scores. had better validity than LWAQ. surprisingly high group performed