S100A7 overexpression is a predictive marker for high risk of malignant transformation in oral dysplasia.
作者： Jatinder Kaur , Ajay Matta , Ipshita Kak , Gunjan Srivastava , Jasmeet Assi
DOI: 10.1002/IJC.28473
关键词: Survival analysis 、 Hazard ratio 、 Oncology 、 Dysplasia 、 Internal medicine 、 Predictive marker 、 Biomarker (medicine) 、 Oral Dysplasia 、 S100A7 、 Biology 、 Malignant transformation 、 Pathology
摘要: Early detection of oral lesions (OLs) at high risk cancer development is utmost importance for intervention. There an urgent unmet clinical need biomarkers that allow identification high-risk OLs. Recently, we identified and verified a panel five candidate protein namely S100A7, prothymosin alpha, 14-3-3ζ, 14-3-3σ heterogeneous nuclear ribonucleoprotein K using proteomics to distinguish OLs with dysplasia cancers from normal tissues. The objective our study was evaluate the potential these dysplastic development. Using immunohistochemistry, analyzed expressions in 110 patients biopsy-proven known outcome determined their correlations p16 expression HPV 16/18 status. Kaplan–Meier survival analysis showed reduced cancer-free (OCFS) 68.6 months (p = 0.007) showing cytoplasmic S100A7 overexpression when compared weak or no immunostaining cytoplasm (mean OCFS 122.8 months). Multivariate Cox regression revealed as most significant marker associated 0.041, hazard ratio 2.36). In conclusion, suggested identifying
dissem.in参考文章(50)
S. Warnakulasuriya, J. Reibel, J. Bouquot, E. Dabelsteen, Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. Journal of Oral Pathology & Medicine. ,vol. 37, pp. 127- 133 ,(2008) , 10.1111/J.1600-0714.2007.00584.X
S. Warnakulasuriya, T. Kovacevic, P. Madden, V. H. Coupland, M. Sperandio, E. Odell, H. Møller, Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10‐year period in South East England Journal of Oral Pathology & Medicine. ,vol. 40, pp. 677- 683 ,(2011) , 10.1111/J.1600-0714.2011.01054.X
Aykut Tahtali, Christiane Hey, Martin Leinung, Jens Wagenblast, Marc Diensthuber, Timo Stöver, Natalie Filman, Christin Geissler, HPV Status and Overall Survival of Patients with Oropharyngeal Squamous Cell Carcinoma - A Retrospective Study of a German Head and Neck Cancer Center Anticancer Research. ,vol. 33, pp. 3481- 3485 ,(2013)
Aykut Tahtali, Jens Wagenblast, Marc Diensthuber, Davina Gassner, Timo Stöver, Christin Geißler, The Role of p16 Expression as a Predictive Marker in HPV-positive Oral SCCHN – A Retrospective Single-center Study Anticancer Research. ,vol. 33, pp. 913- 916 ,(2013)
M. P ROSIN, C. F POH, M. GUILLARD, P MICHELE WILLIAMS, L. ZHANG, C. MACAULAY, Visualization and other emerging technologies as change makers for oral cancer prevention. Annals of the New York Academy of Sciences. ,vol. 1098, pp. 167- 183 ,(2007) , 10.1196/ANNALS.1384.039
Ajay Matta, Leroi V. DeSouza, Nootan Kumar Shukla, Siddhartha D. Gupta, Ranju Ralhan, K. W. Michael Siu, Prognostic significance of head-and-neck cancer biomarkers previously discovered and identified using iTRAQ-labeling and multidimensional liquid chromatography-tandem mass spectrometry. Journal of Proteome Research. ,vol. 7, pp. 2078- 2087 ,(2008) , 10.1021/PR7007797
Lin Ye, Ping-Hui Sun, Tracey A. Martin, Andrew J. Sanders, Malcolm D. Mason, Wen G. Jiang, Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells Urologic Oncology: Seminars and Original Investigations. ,vol. 31, pp. 1576- 1583 ,(2013) , 10.1016/J.UROLONC.2012.05.006
Vijayvel Jayaprakash, Mary Reid, Elizabeth Hatton, Mihai Merzianu, Nestor Rigual, James Marshall, Steve Gill, Jennifer Frustino, Gregory Wilding, Thom Loree, Saurin Popat, Maureen Sullivan, Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: a meta-analysis, 1985-2010 Oral Oncology. ,vol. 47, pp. 1048- 1054 ,(2011) , 10.1016/J.ORALONCOLOGY.2011.07.009
Alyson K. Freeman, Deborah K. Morrison, 14-3-3 Proteins: Diverse functions in cell proliferation and cancer progression Seminars in Cell & Developmental Biology. ,vol. 22, pp. 681- 687 ,(2011) , 10.1016/J.SEMCDB.2011.08.009
G Zhou, T-X Xie, M Zhao, S A Jasser, M N Younes, D Sano, J Lin, M E Kupferman, A A Santillan, V Patel, J S Gutkind, A K EI-Naggar, E D Emberley, P H Watson, S-I Matsuzawa, J C Reed, J N Myers, Reciprocal negative regulation between S100A7/psoriasin and β-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity Oncogene. ,vol. 27, pp. 3527- 3538 ,(2008) , 10.1038/SJ.ONC.1211015