Prognostic significance of head-and-neck cancer biomarkers previously discovered and identified using iTRAQ-labeling and multidimensional liquid chromatography-tandem mass spectrometry.
作者： Ajay Matta , Leroi V. DeSouza , Nootan Kumar Shukla , Siddhartha D. Gupta , Ranju Ralhan
DOI: 10.1021/PR7007797
关键词:
摘要: Diagnostic oncoproteomics is an emerging field; at present, studies on evaluation of prognostic utility potential biomarkers identified using proteomic techniques are limited. Analysis with isobaric mass tags (iTRAQ) by multidimensional liquid chromatography−mass spectrometry (LC−MS/MS) to identify proteins that differentially expressed in human head-and-neck/oral squamous cell carcinomas (HNOSCCs) versus noncancerous head-and-neck tissues has led the discovery, identification, and verification consistently increased expression a panel proteins, including stratifin (14-3-3σ) YWHAZ (14-3-3ζ), may serve as cancer biomarkers. Herein, we describe these two candidate for carcinoma (HNOSCC). To determine clinical significance tumorigenesis, expressions were analyzed HNOSCCs (51 cases) nonmalignant (39 immunoh...
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