Targeting of chemoprevention to high-risk potentially malignant oral lesions: Challenges and opportunities

摘要: summary Worldwide, oral cancer is responsible for 170,000 deaths per year. Intervention to prevent this disease a long sought after goal. Chemoprevention studies have focused on clinicopathological features of potentially malignant lesions (PML) in an effort their progression cancer. However, prediction future behavior such difficult and remains major challenge intervention. Different approaches problem been tested the past 20 years. Early genetic models identified critical regions allelic imbalance at 3p 9p, provided basis molecular markers identify progressing PMLs. Subsequently, technological advances, as genome-wide high-throughput array platforms, computer imaging, visualization technology next generation sequencing, broadened scope marker development potential further improving our ability high-risk near either alone or combination. In article, we examine milestones PML progression. We emphasize importance networks among scientists, health professionals community facilitate validation application putative into clinical practice. With growing number new agents validate, it necessary coordinate design implementation strategies patient recruitment, integration assessment, final translation use.