Osteoporosis risk factors, gynaecological history and fractures in perimenopausal women--the results of the baseline postal enquiry of the Kuopio Osteoporosis Risk Factor and Prevention Study.

摘要: Abstract The Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study examines the risk factors of osteoporosis, relationship to bone density fractures, as well possibility prevent loss by administering certain hormones. baseline postal enquiry in 1989 was sent all 14 220 women aged 47–56 years residing Province, Finland. questionnaire included questions about their gynaecological history, physical exercise smoking habits, calcium intake, body weight height, history health disorders, current previous use drugs, willingness participate densitometry a clinical hormone trial. response rate 92.8%. In all, 56% reported some female Strong contraindications for oestrogen replacement therapy were found 9.3% women. Almost half respondents lack regular exercise, 11.9% smokers, 17.0% intake from milk products less than 500 mg daily. incidence fractures increased steadily with age. premenopausal within last 10 7.65 per 1000 person/years that postmenopausal 17.40 (P = 0.000). effect menopause on fracture stronger 5-year age increase. Of respondents, 84.4% willing 68.3% long-term prevention osteoporosis oestrogen.