Regulatory interfaces between the stress protein response and other gene expression programs in the cell.

摘要: The stress protein response involves the immediate reprogramming of gene expression in cells exposed to proteomic insult leading massive synthesis heat shock proteins (HSP). We have examined outcome when are induced activate two other programs--the acute inflammatory and entry quiescent into cell cycle--and then stress. find that these responses mutually antagonistic with, on one hand, factor 1 (HSF1) inhibition through phosphorylation inhibitory serine residues after or mitogenic stimulus and, stress, HSF1 directly repressing promoters genes mediate inflammation mitogenesis. during periods damage was shown lead efficient activation HSP accompanied by repression programs.