Monoamine oxidase inhibition: Possible mechanism for cyproheptadine-induced alterations in insulin secretion
作者： Jerome M. Feldman , Barbara A. Chapman , James W. Plonk
DOI: 10.1016/S0024-3205(74)80009-3
关键词: Monoamine oxidase 、 Hamster 、 Pancreatic islets 、 Internal medicine 、 Serotonin Antagonists 、 Cinanserin 、 Methysergide 、 Endocrinology 、 Biology 、 Cyproheptadine 、 Golden hamster
摘要: Summary Studies were carried out to determine the mechanism of cyproheptadine (CYPRO) inhibition glucose-stimulated insulin secretion in golden hamster. Following CYPRO injection, intact hamsters have an increase serum glucose concentration and secretion. Using homogenates isolated pancreatic islets liver from rabbits we found that is a competitive inhibitor monoamine oxidase (MAO). There significant correlation between inhibitory potency serotonin antagonists CYPRO, cinanserin (CINAN), methysergide (METHY) on vitro hamster pancreas MAO effect these compounds. The decreasing order as inhibitors is: > CINAN METHY. antihistaminic agents diphenhydramine chlorpheniramine also inhibit activity. Our studies suggest net different species may be results interaction its antiserotonin properties.
sci-hub.se 参考文章(21)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
John N. Stiel, Grant W. Liddle, William W. Lacy, Studies of Mechanism of Cyproheptadine-induced Weight Gain in Human Subjects Metabolism-clinical and Experimental. ,vol. 19, pp. 192- 200 ,(1970) , 10.1016/0026-0495(70)90052-1
Sidney Udenfriend, Bernard Witkop, Betty G. Redfield, Herbert Weissbach, Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds Biochemical Pharmacology. ,vol. 1, pp. 160- 165 ,(1958) , 10.1016/0006-2952(58)90025-X
J. M. Feldman, K. E. Quickel, Effects of amino acids, epinephrine and heparin upon the radioimmunoassay of insulin in plasma. Diabetes. ,vol. 22, pp. 9- 15 ,(1973) , 10.2337/DIAB.22.1.9
Richard J. Wurtman, Julius Axelrod, A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE. Biochemical Pharmacology. ,vol. 12, pp. 1439- 1441 ,(1963) , 10.1016/0006-2952(63)90215-6
J. M. Feldman, K. E. Quickel, H. E. Lebovitz, Potentiation of Insulin Secretion in Vitro by Serotonin Antagonists Diabetes. ,vol. 21, pp. 779- 788 ,(1972) , 10.2337/DIAB.21.7.779
KENNETH E. QUICKEL, JEROME M. FELDMAN, HAROLD E. LEBOVITZ, Inhibition of insulin secretion by serotonin and dopamine: species variation. Endocrinology. ,vol. 89, pp. 1295- 1302 ,(1971) , 10.1210/ENDO-89-5-1295
J.S. Wold, D.S. Longnecker, L.J. Fischer, Species dependent pancreatic islet toxicity produced by cyproheptadine: Alterations in beta cell structure and function Toxicology and Applied Pharmacology. ,vol. 19, pp. 188- 201 ,(1971) , 10.1016/0041-008X(71)90106-2
J. M. Feldman, H. E. Lebovitz, Specificity of Serotonin Inhibition of Insulin Release from Golden Hamster Pancreas Diabetes. ,vol. 19, pp. 475- 479 ,(1970) , 10.2337/DIAB.19.7.475
EDITH D. HENDLEY, SOLOMON H. SNYDER, Relationship between the Action of Monoamine Oxidase Inhibitors on the Noradrenaline Uptake System and their Antidepressant Efficacy Nature. ,vol. 220, pp. 1330- 1331 ,(1968) , 10.1038/2201330A0