Value of Intact Prostate Specific Antigen and Human Kallikrein 2 in the 4 Kallikrein Predictive Model: An Individual Patient Data Meta-Analysis

作者: Andrew Vickers , Emily A. Vertosick , Daniel D. Sjoberg , Freddie Hamdy , David Neal

DOI: 10.1016/J.JURO.2018.01.070

关键词: BiopsyKallikreinInternal medicineOncologyRectal examinationProstateCancerProstate biopsyProstate-specific antigenProstate cancerMedicineUrology

摘要: Purpose: The 4 kallikrein panel, commercially available as the 4Kscore®, is a statistical model that has been shown to accurately predict Gleason Grade Group 2 or greater (high grade) cancer on biopsy and long-term risk of distant prostate metastases. panel includes novel markers, namely intact specific antigen hK2. It questioned whether these additional markers add discrimination clinical predictors patient age, digital rectal examination prior biopsy, established molecular total free antigen.Materials Methods: We performed an individual data meta-analysis published studies in which was measured men undergoing biopsy. assess improvement associated with including hK2 along model.Results: Included analysis were 14,510 from ...

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