Properties of the 4-Kallikrein Panel Outside the Diagnostic Gray Zone: Meta-Analysis of Patients with Positive Digital Rectal Examination or Prostate Specific Antigen 10 ng/ml and Above
作者： Andrew Vickers , Emily A. Vertosick , Daniel D. Sjoberg , Monique J. Roobol , Freddie Hamdy
DOI: 10.1016/J.JURO.2016.09.086
关键词:
摘要: Purpose: The 4-kallikrein panel, commercially available as the 4Kscore™, is a reflex test for prostate cancer early detection that has been extensively validated in multiple international cohorts. It suggested use of such tests be limited to those with specific antigen less than 10 ng/ml and negative digital rectal examination. We aimed determine value panel men outside this “diagnostic gray zone.”Materials Methods: performed an individual patient data meta-analysis using from prior studies on panel. calculated properties predicting high grade (Gleason 7+) subgroup either positive examination or 25 ng/ml.Results: A total 2,891 8 cohorts were included. An important proportion patients, including 32% United States validation study, had For...
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