p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis
作者： Sahar S Bhat , Deepak Anand , Firdous A Khanday
DOI: 10.1186/S12943-015-0354-9
关键词: Signal transducing adaptor protein 、 Intracellular 、 Signal transduction 、 Cell signaling 、 Biology 、 Shc Signaling Adaptor Proteins 、 Cell 、 Cell biology 、 Proto-oncogene tyrosine-protein kinase Src 、 Cell growth
摘要: … All these studies point to the fact that p66Shc is needed for bringing about apoptosis. Phosphorylation of p66Shc on the S36 residue has been shown to have a pro-apoptotic effect in …
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