Interaction of magnesium-based materials with human blood cells and culture of human diploid cells in vitro

摘要: We studied morphofunctional properties of human blood cells and diploid culture exposed to different types magnesium materials: pure (Mg), magnesium—yttrium—neodymium—zirconium alloy (Mg-Y-Nd-Zr) magnesium—zinc—calcium (Mg-Zn-Ca). The materials were incubated with donor mesenchymal multipotent stromal over 3 days. did not induce massive lysis erythrocytes leukocytes in vitro, but gradually impaired their structural integrity. In all cases, spontaneous platelet aggregation was observed 6 h. the presence Mg Mg-Zn-Ca alloy, this accompanied by a decrease number platelets granules. 24 h, substantial degranulation occurred cases 72 contain parallel, formation large aggregates (60 μ) observed. cells, Mg-based reduced integrity significantly inhibit cell proliferation. Structural partially recovered day culture. (Mg, Mg-Y-Nd-Zr, Mg-Zn-Ca) seemed be low-toxic for during short-term contact, could stimulate viability vitro.