Nanoparticle Properties Modulate Their Effect on the Human Blood Functions

摘要: Theranostic nanoparticles (NPs) can reach their target tissue only by passing through blood. However, the influence of NPs on blood is still not well understood. Understanding effects functioning critical for successful translation this novel drug delivery paradigm. In article, we examined potential effect components using four physically and chemically diverse such as carbon nanotube (CNT), magnesium (Mg), silver (Ag), copper oxide (CuO) NPs. The interaction different was studied under similar conditions assessed determining total protein, alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cholesterol, electrolytes Na+, K+, Cl- concentrations in concentration AST, did show any significant change when exposed to On other hand, ALT ALP declined Ag CuO Cholesterol levels significantly CNT, Mg, K+ increased over 24 h Mg but remained consistent Such an increase induced be attributed direct with RBCs blood, resulting hemolysis. Overall, results suggest that physical chemical natures are factors influencing between components.