Do rats have prefrontal cortex? the rose-woolsey-akert program reconsidered

摘要: Primates are unique among mammals in possessing a region of dorsolateral prefrontal cortex with well-developed internal granular layer. This is commonly implicated higher cognitive functions. Despite the histological distinctiveness primate cortex, work Rose, Woolsey, and Akert produced broad consensus neuroscientists that homologues frontal exist nonprimates can be recognized by their dense innervation from mediodorsal thalamic nucleus (MD). Additional characteristics have come to identified including rich dopaminergic involvement spatial delayed-reaction tasks. However, recent studies reveal these not distinctive primates: MD projections widespread lobe, medial orbital areas may play role delay A reevaluation rat suggests usually considered homologous primates, actually consists premotor anterior cin-date cortex. The lateral MD-projection rats resembles portions If construed broadly enough include cingulate said they evidently lack primates. assessment probably do provide useful models human lobe function dysfunction, although might prove valuable for understanding other regions