Microcirculation, vitamin E and omega 3 fatty acids: an overview.

摘要: We have observed significant increases in LDF and similar trends for CBV after FO supplementation younger subjects (both normolipidemic hyperlipidemic). In elderly subjects, this trend appears to be reversed unless are supplemented with higher doses of vit. E (100 IU/10 KG/day). Our mouse data suggest that dietary at 100 IU/Kg does not adequately protect against lipid oxidation vivo or vitro following an oxidative insult when mice fed 8% & 2% linoleic acid containing diet. It has been reported significantly lowers triglycerides VLDL-cholesterol (especially where initial triglyceride values) tends increase LDL-cholesterol Apo-B100. These findings all the more important because LDL from FO-supplemented caused a time-dependent ability facilitate albumin transfer which was diminished 2 month washout (WO). Addition supplement prevented change. without sufficient may deleterious vascular endothelium. The western fat blend appeared protective increased length most likely due MONO fatty acids resistant oxidation; little additional effect. combined studies, those by others, humans, peripheral microcirculatory flow is changes precapillary tone i.e., vasodilation. also possible subtle each three variables i.e. blood pressure, viscosity contribute we noted as intervention n-3 acids. hypothesize interactions between alters ratios vasoconstrictive-platelet aggegatory/vasodilatory-antiplatelet aggregatory agents (TXA2 endothelin/PGI2 nitric oxide), expression adhesion molecules (P-selectin E-selectin) thereby directly influences modulation free radical mediated events elements Fatty n3 series alter these favoring production vasodilatory compounds decreased P and/or E-selectins, provided highly oxidizable lipids protected adequate antioxidants.