Sulfatide as a biochemical marker in cerebrospinal fluid of patients with vascular dementia.
作者： P. Fredman , A. Wallin , K. Blennow , P. Davidsson , CG. Gottfries
DOI: 10.1111/J.1600-0404.1992.TB04006.X
关键词: Endocrinology 、 Glycosphingolipid 、 Pathology 、 Vascular dementia 、 Cerebral infarction 、 Cerebrospinal fluid 、 Alzheimer's disease 、 Dementia 、 Diagnostico diferencial 、 Degenerative disease 、 Medicine 、 Internal medicine
摘要: The myelin-associated glycosphingolipid sulfatide in cerebrospinal fluid (CSF) was investigated 20 patients with vascular dementia (VAD), 43 Alzheimer's disease (AD) and age-matched controls. concentration the VAD group (307 +/- 118 nmol/l) significantly (p less than 0.0001) higher that controls (145 86 AD (178 79 nmol/l). Among patients, 8/20 had a increased of (greater mean + 2 S.D.), as compared controls, while only 2/43 above this level. It is suggested elevated CSF from reflects demyelination. Furthermore, determinations, when combined clinical findings, may be diagnostic value, for discriminating between AD.
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