作者: Charles A Janeway
DOI: 10.1016/S0960-9822(99)80209-7
关键词: Negative selection 、 Biology 、 Computational biology 、 T cell 、 Positive selection 、 Repertoire 、 Cellular differentiation 、 Receptor
摘要: An important issue for immunologists is the difference between two main processes that determine mature repertoire of T-cell receptors, termed positive and negative selection. Recent papers have addressed role self-peptides in process