PH/temperature-responsive fluorescence polymer probe with pH-controlled cellular uptake
作者： Yuki Hiruta , Takaaki Funatsu , Minami Matsuura , Jian Wang , Eri Ayano
DOI: 10.1016/J.SNB.2014.10.065
关键词: Polymer 、 Intracellular 、 Chain transfer 、 Inorganic chemistry 、 Chemistry 、 Polymerization 、 Fluorescence 、 Raft 、 Lower critical solution temperature 、 Polymer chemistry
摘要: Abstract A pH/temperature-responsive fluorescence polymer, I 42 D 50 S 8 -FL, consisting of N -isopropylacrylamide, , -dimethylacrylamide, and sulfamethazineacrylamide was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization, followed activation terminal carboxyl groups with -hydroxysuccinimide reaction 5-aminofluorescein (FL). -FL exhibited a pH-dependent phase transition across the lower critical solution temperature (LCST), specific intracellular uptake observed only in weak acidic conditions. has potential to be applied for selective imaging tumor microenvironments.
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