Energy barriers and cell migration in densely packed tissues.

摘要: Recent observations demonstrate that confluent tissues exhibit features of glassy dynamics, such as caging behavior and dynamical heterogeneities, although it has remained unclear how single-cell properties control this behavior. Here we develop numerical theoretical models to calculate energy barriers cell rearrangements, which help govern migration in monolayers. In contrast work on sheared foams, find barrier heights are exponentially distributed depend systematically the cell's number neighbors. Based these results, predict two-time correlation functions for motion, with a timescale increases rapidly activity decreases. These used construct simple random walks reproduce observed trajectories experiments. This provides framework predicting collective motion cells wound-healing, embryogenesis cancer tumorogenesis.