Slow and anomalous dynamics of an MCF-10A epithelial cell monolayer

摘要: Understanding the mechanics and dynamics of active matter at high density is indispensable to a range physical biological processes such as swarm dynamics, tissue formation cancer metastasis. Here, we study an MCF-10A epithelial cell monolayer on multi-cellular single-cell scales over wide range. We show that Young's modulus are spatially heterogeneous scale. With increasing density, approached kinetic arrest scaled critically. On scale, increased, cells were intermittently trapped in cages formed by their neighbors motion evolved from ballistic sub-diffusive motion. Furthermore, relaxation time inverse self-diffusivity increased exponentially with density. These findings provide mechanism for long-ranged mechanical stress propagation, remodeling patterning very densities.