Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation.
作者： Nathan Lamarre-Vincent , Linda C. Hsieh-Wilson
DOI: 10.1021/JA028200T
关键词: Cell biology 、 Information storage 、 Transcription factor 、 Glycosylation 、 In vitro 、 Chemistry 、 ATF/CREB 、 Molecular biology 、 Regulation of gene expression 、 Gene 、 CREB
摘要: We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within Q2 domain and disrupts interaction between TAF_(II)130, thereby repressing transcriptional activity of vitro. These findings have important implications role glycosylation gene regulation, they provide link information storage processes
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