The Prognostic Significance of Beta2 Microglobulin in Patients with Hemophagocytic Lymphohistiocytosis.

摘要: Objective. To determine the prognostic significance of beta2 microglobulin (β2-m) concentrations in patients with hemophagocytic lymphohistiocytosis (HLH), a rare disorder caused by pathologic activation immune system. Patients and Methods. The study population consisted 74 diagnosed HLH 35 healthy controls. Serum β2-m levels were measured using latex agglutination photometric immunoassay. Results. Median serum significantly higher than controls (4.05 versus 1.5 mg/L; ) lymphoma associated syndrome (LAHS) benign disease-associated (4.2 3.3 mg/L; ). Higher positively correlated LAHS ( ), abnormal lactate dehydrogenase hypoalbuminemia ROC analysis showed that overall survival (OS) was shorter ≥4.03 mg/L compared to Moreover, multivariate level an independent OS LAHS. Conclusion. High markedly poorer HLH. concentration powerful factor for