Serum and urine beta---2-microglobulin in hemophagocytic syndrome

摘要: BACKGROUND Previous reports suggesting a correlation between lymphoproliferative disease and serum levels of beta-2-microglobulin (beta-2M) in vitro data indicating role cytokines the production beta-2M prompted study urine concentration patients with hemophagocytic syndrome (HPS), because no were previously available for HPS, pathologic state associated excessive secreted from activated reactive/malignant lymphocytes histiocytes. METHODS Serum measured six children HPS during active convalescent phase other diseases. RESULTS significantly high not only (median, 7.5 mg/l; range, 2.3-16.0 P 31,650 micrograms/gram Creatinine (gCr); 8179-236,333 micrograms/gCr; < 0.01), compared 2.0 0.9-2.5 mg/l median, 338 223-585 micrograms/gCr urine) control subjects diseases such as acute lymphocytic leukemia 2.3 1.0-2.8 327 48-2684 urine), infectious mononucleosis 2.9 2.5-5.5 348 80-1325 Kawasaki 2.8 1.5-3.3 1016 214-4500 urine). Noteworthy was observation that correlated closely activity. CONCLUSIONS Urine appears to be useful marker assessing activity HPS.