Determination of Tricyclic Antidepressants in Human Breast Milk by Capillary Electrophoresis

摘要: A method for the determination of several tricyclic antidepressants (imipramine, desipramine, amitriptyline, nortriptyline, clomipramine, norclomipramine, doxepine and nordoxepine) in breast milk has been developed. This assay consists a common extraction process an organic phase, which is evaporated until dried finally reconstituted appropriate buffer injection capillary electrophoresis system. The used "acetonitrile stacking" previously reported determining these drugs serum samples. developed was applied to analysis compounds human at different concentration levels (50, 100 200 ppb TCAs hydrochlorides). An interference study some ansiolitic such as lorazepam alprazolam made.