Nickel-catalyzed direct arylation of C(sp3)-H bonds in aliphatic amides via bidentate-chelation assistance.
作者： Yoshinori Aihara , Naoto Chatani
DOI: 10.1021/JA411715V
关键词: Nickel 、 Bond cleavage 、 Catalysis 、 Methylene 、 Denticity 、 Organic chemistry 、 Aryl 、 Catalytic cycle 、 Medicinal chemistry 、 Moiety 、 Chemistry
摘要: The Ni-catalyzed, direct arylation of C(sp3)–H (methyl and methylene) bonds in aliphatic amides containing an 8-aminoquinoline moiety as a bidentate directing group with aryl halides is described. Deuterium-labeling experiments indicate that the C–H bond cleavage step fast reversible. Various nickel complexes including both Ni(II) Ni(0) show high catalytic activity. results series mechanistic reaction does not proceed through Ni(0)/Ni(II) cycle, but probably Ni(II)/Ni(IV) cycle.
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