Integration of human sleep-wake regulation and circadian rhythmicity.
作者： Derk-Jan Dijk , Steven W. Lockley
DOI: 10.1152/JAPPLPHYSIOL.00924.2001
关键词: Suprachiasmatic nucleus 、 Phase response curve 、 Free-running sleep 、 Light effects on circadian rhythm 、 Neuroscience 、 Biology 、 Bacterial circadian rhythms 、 Internal medicine 、 Dark therapy 、 Circadian rhythm 、 Endocrinology 、 Infradian rhythm
摘要: The human sleep-wake cycle is generated by a circadian process, originating from the suprachiasmatic nuclei, in interaction with separate oscillatory process: sleep homeostat. normally timed to occur at specific phase relative external of light-dark exposure. It also internal rhythms, such as pineal melatonin rhythm, propensity and rhythm responsiveness pacemaker light. Variations these relationships, those that blindness, aging, morning evening, advanced delayed sleep-phase syndrome, lead disruptions complaints. Changes ocular photoreception, interindividual variation near-24-h intrinsic period pacemaker, homeostasis can contribute variations phase. Recent findings on physiological molecular-genetic correlates disorders suggest timing rhythms closely integrated but is, part, regulated differentially.
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