Extended LineSets: a visualization technique for the interactive inspection of biological pathways

作者: Francesco Paduano , Angus Forbes

DOI: 10.1186/1753-6561-9-S6-S4

关键词: VisualizationRange (mathematics)Computer scienceData scienceUse caseSet (abstract data type)Domain (software engineering)Human–computer interactionInteractive visual analysisStructure (mathematical logic)Biological pathway

摘要: Biologists make use of pathway visualization tools for a range tasks, including investigating inter-pathway connectivity and retrieving details about biological entities interactions. Some these tasks require an understanding the hierarchical nature elements within or ability to comparisons between multiple pathways. We introduce technique inspired by LineSets that enables biologists fulfill more effectively. novel technique, Extended LineSets, facilitate new explorations Our incorporates intuitive graphical representations different levels information includes well-designed set user interactions selecting, filtering, organizing data gathered from databases. Based on interviews with domain experts analysis two cases, we show our provides functionality not currently enabled current techniques, moreover it helps better understand both structure

参考文章(25)
Tamara Munzner, Visualization Analysis and Design ,(2014)
Zhenjun Hu, Joseph Mellor, Jie Wu, Charles DeLisi, VisANT: An Online Visualization and Analysis Tool for Biological Interaction Data BMC Bioinformatics. ,vol. 5, pp. 17- 17 ,(2004) , 10.1186/1471-2105-5-17
Alexander Lex, Nils Gehlenborg, Hendrik Strobelt, Romain Vuillemot, Hanspeter Pfister, UpSet: Visualization of Intersecting Sets. IEEE Transactions on Visualization and Computer Graphics. ,vol. 20, pp. 1983- 1992 ,(2014) , 10.1109/TVCG.2014.2346248
Antonio Fabregat, Konstantinos Sidiropoulos, Phani Garapati, Marc Gillespie, Kerstin Hausmann, Robin Haw, Bijay Jassal, Steven Jupe, Florian Korninger, Sheldon McKay, Lisa Matthews, Bruce May, Marija Milacic, Karen Rothfels, Veronica Shamovsky, Marissa Webber, Joel Weiser, Mark Williams, Guanming Wu, Lincoln Stein, Henning Hermjakob, Peter D'Eustachio, The Reactome Pathway Knowledgebase. Nucleic Acids Research. ,vol. 44, pp. 472- 477 ,(2014) , 10.1093/NAR/GKV1351
Kiku-e K Tachibana, Michael A Gonzalez, Nicholas Coleman, CELL-CYCLE-DEPENDENT REGULATION OF DNA REPLICATION AND ITS RELEVANCE TO CANCER PATHOLOGY The Journal of Pathology. ,vol. 205, pp. 123- 129 ,(2005) , 10.1002/PATH.1708
Zhenjun Hu, Joe Mellor, Jie Wu, Minoru Kanehisa, Joshua M Stuart, Charles DeLisi, Towards zoomable multidimensional maps of the cell. Nature Biotechnology. ,vol. 25, pp. 547- 554 ,(2007) , 10.1038/NBT1304
William JR Longabaugh, Combing the hairball with BioFabric: a new approach for visualization of large networks BMC Bioinformatics. ,vol. 13, pp. 275- 275 ,(2012) , 10.1186/1471-2105-13-275
Josh Barnes, Piet Hut, A hierarchical O(N log N) force-calculation algorithm Nature. ,vol. 324, pp. 446- 449 ,(1986) , 10.1038/324446A0
Ramik Sadana, Timothy Major, Alistair Dove, John Stasko, OnSet: A Visualization Technique for Large-scale Binary Set Data. IEEE Transactions on Visualization and Computer Graphics. ,vol. 20, pp. 1993- 2002 ,(2014) , 10.1109/TVCG.2014.2346249
Wouter Meulemans, Nathalie Henry Riche, Bettina Speckmann, Basak Alper, Tim Dwyer, KelpFusion: A Hybrid Set Visualization Technique IEEE Transactions on Visualization and Computer Graphics. ,vol. 19, pp. 1846- 1858 ,(2013) , 10.1109/TVCG.2013.76