Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns.

摘要: OBJECTIVE: Two forms of recombinant growth hormone that accelerate the healing skin graft donor sites in severely burned children were evaluated. SUMMARY BACKGROUND DATA: Growth has been shown to reduce wound times pediatric patients. Through genetic engineering, several different have synthesized; however, not all are marketed currently. used these studies, Protropin (Genentech, Inc., San Francisco, CA), a commercially available product possesses N-terminal methionine residue found second form Nutropin which, as yet, is available. use human hormone, rapid may hypermetabolic period, risk infection, and for grafting onto areas. The two structurally tested their efficacy children. METHODS: Forty-six children, with > 40% total body surface area 20% full-thickness burn entered double-blind, randomized study receive rhGH within 8 days injury. Twenty received (0.2 mg/kg/day) or placebo by subcutaneous intramuscular injection beginning on morning initial excision. Eighteen patients who failed entry criteria receiving therapeutically mg/kg/day). Donor harvested at 0.006 0.010 inches depth dressed Scarlet Red impregnated fine mesh gauze (Sherwood Medical, St. Louis, MO). site time, days, was reached when could be removed without any trauma healed site. RESULTS: (n = 20) 18) 6.8 +/- 1.5 6.0 (mean SD) respectively, whereas those 26) had first time 8.5 2.3 days. Both groups showed significant reduction compared p < 0.01. When subgroups compared, no difference regards age admission after CONCLUSION: Our results indicate both effective reducing suggest accelerating clinical benefit because patients' own becomes rapidly harvest autografting. With this increase rate healing, length hospital stay can reduced more than 25%.