Modulation of Dengue Virus Infection of Dendritic Cells by Aedes aegypti Saliva
作者： Daniel B. Ader , Christina Celluzzi , John Bisbing , Lara Gilmore , Vicky Gunther
关键词: Saliva 、 Flavivirus 、 Immunology 、 Vector (molecular biology) 、 Biology 、 Aedes aegypti 、 Virology 、 Transmission (medicine) 、 Dengue fever 、 Antigen-presenting cell 、 Dengue virus 、 Molecular medicine
摘要: Dengue virus (DV) is a flavivirus carried by the Aedes aegypti mosquito that causes spectrum of illnesses in tropics, including dengue fever, hemorrhagic and shock syndrome. Dendritic cells (DCs) are professional antigen presenting recently shown to be permissive for DV, implicated as primary targets initial DV infection. transmitted human host infected mosquitoes during blood meal, but it currently unknown whether transmission modified vector saliva also deposited host's skin feeding. Previous studies evaluated only outcome infection DCs, did not address influence saliva. To more fully characterize natural we effects Ae. on myeloid DCs. We found inhibited Moreover, pre-sensitization DCs with saliva, prior infection, enhanced inhibition. In addition, production o...
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