Insight into the Functional Consequences of Inherited Variants of the hMYH Adenine Glycosylase Associated with Colorectal Cancer: Complementation Assays with hMYH Variants and Pre-steady-state Kinetics of the Corresponding Mutated E.coli Enzymes
作者： Nikolas H Chmiel , Alison L Livingston , Sheila S David
DOI: 10.1016/S0022-2836(03)00124-4
关键词: DNA glycosylase 、 Guanine 、 Familial adenomatous polyposis 、 DNA repair 、 Molecular biology 、 Transversion 、 Adenomatous polyposis coli 、 Complementation 、 Chemistry 、 Genetics 、 Mutant
摘要: … a reduced ability of the hMYH variants compared to wild-type … If the corresponding mutations in hMYH cause similar … The lack of complementation of the hMYH variants for MutY, and the …
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