Base excision repair and cancer
作者： Susan S. Wallace , Drew L. Murphy , Joann B. Sweasy
DOI: 10.1016/J.CANLET.2011.12.038
关键词:
摘要: Base excision repair is the system used from bacteria to man remove tens of thousands endogenous DNA damages produced daily in each human cell. required for normal mammalian development and defects have been associated with neurological disorders cancer. In this paper we provide an overview short patch base humans summarize current knowledge mouse models functional studies on germ line polymorphisms their relationship The biallelic mutations that result MUTYH-associated colon cancer are also discussed.
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