Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke.

摘要: Hemorrhagic stroke is a life-threatening disease characterized by sudden rupture of cerebral blood vessels, and it widely believed that neural cell death occurs after exposure to metabolites or subsequently damaged cells. Neural stem cells (NSCs), which maintain neurogenesis are found in subgranular zone subventricular zone, thought be an endogenous neuroprotective mechanism for these brain injuries. However, due the complexity NSCs their microenvironment, current strategies cannot satisfactorily enhance functional recovery hemorrhagic stroke. It well known transcriptional genomic pathways play important roles ensuring normal functions NSCs, including proliferation, migration, differentiation, reconnection. Recently, emerging evidence from use new technologies such as next-generation sequencing transcriptome profiling has provided insight into our understanding function regulation NSCs. In present article, we summarize data on control at both levels. Using bioinformatics methods, sought predict novel therapeutic targets exogenous NSC transplantation stroke, could also advance its pathophysiology.