Atrophic body gastritis patients with enterochromaffin-like cell dysplasia are at increased risk for the development of type I gastric carcinoid.

摘要: Background/Aims In the presence of atrophic body gastritis, gastric carcinoid develops from gastric-body mucosa enterochromaffin-like cells. Few data exist on prevalence dysplastic lesions in gastritis patients and their presumed risk evolution to has never been assessed prospectively humans. The aim present study was investigate incidence neoplastic cell a consecutive series with gastritis. Methods A total 130 at diagnosis 96 follow-up (median 30 months) underwent gastroscopy multiple biopsies fasting gastrinaemia evaluation. dysplasia, more detailed bioptic sampling performed. Results Of patients, only one (0.7%) had polyp, whereas dysplasia found five (3.8%). At out (1%) diagnosed as having polyp 41 months. Enterochromaffin-like four additional (4.2%). Two pernicious anaemia developed follow-up. Among nine tumour 22% compared 1.1% without (odds ratio: 26.00; 95% confidence interval: 2.089–323.52). During follow-up, gastrin levels increased significantly (mean 677.4 ± 66.1 vs 1112.2 185.6;P = 0.0287). Conclusion This provides first clinical evidence that, hypergastrinaemic carries markedly for development type I carcinoid. suggests that endoscopic/bioptic procedure this subgroup is able detect an early stage.